TB-500: the synthetic molecule of the active region of thymosin β4

Cas：885340-08-9

Molecular formula: C38H68N10O14

Molecular weight: 889.02

TB-500 is considered the main spherical actin (G-actin) binding peptide, which can bind to G-actin monomers and block its polymerization. TB-500 has multiple biological functions, such as promoting angiogenesis, wound healing, corneal repair, inhibiting inflammation, and regulating tumor metastasis.

Original Research Institute:

TB-500 is a short peptide artificially synthesized by scientists based on their understanding of Tβ4 function, corresponding to amino acid residues 17 to 23 of Tβ4. Its goal is to obtain a smaller, more stable molecule for research while preserving core biological activity. Therefore, TB-500 does not have a single original drug manufacturer; it is the product of basic scientific research and is currently supplied as a research chemical by numerous biotechnology companies worldwide. 

Clinical trials:

TB-500, as this specific 7-peptide molecule, currently has no human clinical trials registered or approved by mainstream pharmaceutical regulatory agencies (such as the US FDA).

Synthesis:

The standard synthesis method for TB-500 is Solid-Phase Peptide Synthesis (SPPS).

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