GHK-Cu: a composite of metal copper ions and tripeptides.

Cas: 89030-95-5

Molecular formula: C14H21CuN6O4

Molecular weight: 400.91

Copper peptide GHK-Cu is a composite of metal copper ions and tripeptides. Due to its abundance of non-ferrous copper ions, blue copper peptides exhibit a unique and elegant blue color; they are the earliest peptides discovered with cosmetic effects. The copper peptide GHK-Cu has a very small molecular weight and is more easily absorbed by the skin.

Original Research Institute:

The discovery of GHK-Cu is credited to American scientist Dr. Lauren Picart. Loren Pickart）。

Follow-up research: Subsequent studies have found that it has wound repair functions. In 1986, ProCyte was established, dedicated to applying GHK-Cu in areas such as tissue repair, anti-aging, and hair growth.

Clinical trials:

It has entered Phase 2 clinical trials.

Synthesis:

GHK-Cu synthesis usually involves two steps: first synthesizing GHK tripeptides, then binding to copper ions.

GHK tripeptide synthesis: The main methods are standard solid-phase peptide synthesis (SPPS) or liquid-phase synthesis methods to synthesize GHK tripeptides. Both methods are mature peptide synthesis technologies.

Binding (complexation) with copper ions: The purified GHK tripeptide reacts with compounds containing copper ions (such as copper acetate, copper hydroxide, etc.) in solution. GHK tripeptides have a strong affinity for copper ions (Cu²⁺) and can spontaneously form stable GHK-Cu complexes. After the reaction is complete, purification is carried out through filtration, freeze-drying, and other methods.

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