Semaglutide

There are two approaches to synthesize semaglutide, fermentation and SPPS.

For fermentation, the main raw materials are as below:

tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu  Cas: 1118767-16-0

Boc-His(Trt)-Aib-OH  Cas: 2061897-68-3

Boc-His(Boc)-Aib-OH  Cas: 1169630-98-1

P29  Cas: 1169630-82-3

For SPPS, the main raw materials are as below:

Fmoc-Lys(Oct-(OtBu)-  -Glu(OtBu)-AEEA-AEEA)-OH  Cas:1662688-20-1

Boc-His(Trt)-Aib-Glu(OtBu)-Gly-OH  Cas:1890228-73-5